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A Practical Guide to the Histology of the Mouse by Cheryl L. Scudamore

By Cheryl L. Scudamore

A sensible advisor to the Histology of the Mouse provides a full-colour atlas of mouse histology. Mouse types of affliction are used widely in biomedical study with many hundreds and hundreds of latest types being generated every year. whole phenotypic research of all of those versions can take advantage of histologic overview of the tissues.

This e-book is aimed toward veterinary and scientific pathologists who're unusual with mouse tissues and scientists who desire to assessment their very own mouse versions. It presents useful advice at the assortment, sampling and research of mouse tissue samples with the intention to maximize the data that may be won from those tissues. in addition to illustrating the conventional microscopic anatomy of the mouse, the booklet additionally describes and explains the typical anatomic diversifications, artefacts linked to tissue assortment and history lesions to aid the scientist to tell apart those adjustments from experimentally- triggered lesions.

This might be a necessary bench-side better half for researchers and practitioners trying to find an available and well-illustrated consultant to mouse pathology.

  • Written by means of skilled pathologists and in particular adapted to the desires of scientists and histologists
  • Full color throughout
  • Provides recommendation on sampling tissues, necropsy and recording data
  • Includes universal anatomic diversifications, heritage lesions and artefacts that allows you to aid non-experts comprehend even if histologic adaptations visible are a part of the traditional historical past or on the topic of their experimental manipulation

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Extra info for A Practical Guide to the Histology of the Mouse

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1979) Cardiac puncture in the mouse through the anterior thoracic aperture. Lab Animal 13, 311–312. J. W. (1975) Spontaneous epicardial mineralization in BALB/cStCrl mice. Laboratory Animal Science 25, 787. H. M. (1988) Color Atlas of Neoplastic and Non-Neoplastic Lesions in Aging Mice, Elsevier, Amsterdam. , et al. (1984) Inheritance of hydronephrosis in the inbred mouse strain DDD. Lab Animal 18, 22–25. E, Bolon, B. D. M. Treuting and S. Dintzis), Elsevier, Amsterdam, pp. 339–394. A. (2000) Chemical fixation, in Principles and Techniques of Electron Microscopy.

It is important that the expectations for the histopathology results are discussed with the pathologist before tissue blocks and sections are made so that the selection and trimming of tissues can be optimized before embedding. Although it is possible to reorientate embedded tissues by melting the paraffin wax and re-embedding it is inevitably more difficult to re-orientate small pieces of trimmed tissue at this stage and impossible to change the sample or retrieve other parts of tissues which have been disposed of after necropsy.

The kidneys from male animals are larger than the kidneys from female mice. Some strains of ageing C57BL/6 mice are reported to demonstrate a high incidence of chronic progressive nephropathy in both male and female mice (Zurcher et al. 1982). 34 Distended urinary bladder in the mouse. 32 Small, shrunken, firm, pale-yellow kidneys with a roughened granular surface. 35 Swelling of the prepuce in the male mouse. 33 Hydronephrosis in the mouse kidney. The urinary bladder is situated above the prostate gland in the male animal and above and attached to the vagina in the female animal.

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