By Honghui Zhou, Frank-Peter Theil
With an emphasis at the primary and useful features of ADME for healing proteins, this booklet is helping readers strategize, plan and enforce translational study for biologic drugs.
• Details state-of-the-art ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs
• Combines theoretical with functional points of ADME in biologic drug discovery and improvement and compares innovator biologics with biosimilar biologics and small molecules with biologics, giving a lessons-learned viewpoint
• Includes case reviews approximately leveraging ADME to enhance biologics drug improvement for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines
• Presents regulatory expectancies and views for constructing biologic medicines in united states, european, and Japan
• Provides mechanistic perception into biodistribution and target-driven pharmacokinetics in very important websites of motion corresponding to tumors and the brain
Read Online or Download ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins: Applications in Drug Discovery and Development PDF
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Additional resources for ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins: Applications in Drug Discovery and Development
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B) Schematic of IgG molecule showing derivation of the major antibody fragments. Color scheme is as for (a). The fragments shown are the Fab (fragment antigen binding), the scFv (single‐chain variable fragment), the dsFv (disulfide‐linked variable fragment), and the VH/VL (variable heavy/variable light, single domains). ) 16 PROTEIN ENGINEERING: APPLICATIONS TO THERAPEUTIC PROTEINS AND ANTIBODIES improved antigen binding, cross‐reactivity between species or increased stability. This selection for improvements enables the use of random sequence modifications to introduce variation into the library, such as those generated by error‐prone PCR .
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