Posted in Developmental Biology

Anaerobiosis and Stemness: An Evolutionary Paradigm for by Zoran Ivanovic, Marija Vlaski-Lafarge

By Zoran Ivanovic, Marija Vlaski-Lafarge

Anaerobiosis and Stemness: An evolutionary paradigm presents a context for knowing the various complexities and evolutionary good points of stem cells and the medical implications of anaerobiosis stem cells.  Combining theoretical and experimental wisdom, the authors supply a vast figuring out of the way the absence or low focus of oxygen can play an influential position within the upkeep and self-renewal of stem cells and stem cellphone differentiation.  This knowing has scientific implications for the fields of regenerative medication, melanoma biology and transplantation, in addition to cellphone engineering and mobile treatment. Anaerobiosis and Stemness is a crucial source for stem mobile and developmental biologists alike, in addition to oncologists, melanoma biologists, and researchers utilizing stem cells for regeneration.

  • Highlights the molecular and evolutionary gains of stem cells which cause them to so very important to all organic research
  • Explores equipment of isolation, characterization, activation, and upkeep of stem cells
  • Includes types for medical software in regenerative medication, melanoma treatment, and transplantation

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Extra info for Anaerobiosis and Stemness: An Evolutionary Paradigm for Therapeutic Applications

Example text

Similarly, the faster proliferation and better maintenance of undifferentiated characteristics and the differentiation potential of the human Wharton’s jelly-derived MStroC was evidenced in 2–3% O2 compared to 20–21% O2 cultures from 1 to 9 passages (the passage 0 appears to have been performed in 20–21% O2) [102], which was associated with a gene expression profile consistent with mesodermal/endothelial fate: several stem cells markers and early mesodermal/endothelial genes such as DESMIN, CD34, and ACTC were up-­regulated (the total MStroC population analyzed).

Cell Stem Cell 2010;7:391–402. [54] Jang YY, Sharkis SJ. A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche. Blood 2007;110:3056–63. [55] Forristal CE, Nowlan B, Jacobsen RN, Barbier V, Walkinshaw G, Walkley CR, et al. HIF-1α is required for hematopoietic stem cell mobilization and 4-prolyl hydroxylase inhibitors enhance mobilization by stabilizing HIF-1α. Leukemia January 12, 2015. 8. [56] Simsek T, Kocabas F, Zheng J, Deberardinis RJ, Mahmoud AI, Olson EN, et al.

69] Jun EK, Zhang Q, Yoon BS, Moon JH, Lee G, Park G, et al. Hypoxic conditioned medium from human amniotic fluid-derived mesenchymal stem cells accelerates skin wound healing through TGF-β/SMAD2 and PI3K/Akt pathways. Int J Mol Sci 2014;15:605–28. [70] Rehn M, Olsson A, Reckzeh K, Diffner E, Carmeliet P, Landberg G, et al. Hypoxic induction of vascular endothelial growth factor regulates murine hematopoietic stem cell function in the low-oxygenic niche. Blood 2011;118:1534–43. [71] Allalunis MJ, Chapman JD, Turner AR.

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