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Cell Death Proteins, Edition: 1st by Gerald Litwack (Eds.)

By Gerald Litwack (Eds.)

Telephone demise is among the basic tactics through which general improvement is modulated, and the significance of either necrosis and apoptosis in a few pathologies has generated extreme curiosity from researchers in lots of fields. This well timed booklet covers either the proteins which are produced by way of demise cells and the proteins that sign cells to begin mobile death.Cell dying Proteins offers an summary of the explosive curiosity in mobile loss of life. Six evaluation papers, written by means of researchers on the vanguard of this swiftly relocating box, specialise in proteins that advertise, sign, and inhibit mobile dying. significant gamers desirous about the telephone demise cascade and its controls are lined, together with cellphone cycle checkpoints, the functionality of interleukin-1J changing enzyme, the function of IGF-I receptor, the Bcl-2 relations of proteins, viral inhibitors of apoptosis, and p53-dependent apoptosis.

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Housman, D. , Koch, C. , Lowe, S. , and Giaccia, A. J . (1996). Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumors. Nature (London) 379,88-91. Hannon, G. , and Beach, D. (1994). plXINK4B) is a potential effector of TGF-beta induced cell cycle arrest. Nature (London) 371, 257-261. Harari, P. , and Kinsella, T. J . (1995). Advances in radiation therapy for head and neck cancer. Curr Opin. Oncol. 7, 248-254. , Bennett, M. , and Evan, G. I. c-Myc-induced apoptosis in fibroblasts in inhibited by specific cytokines.

Evans, D. , Milner, A. , and Wyllie,A. H. (1992). Analysis and discriminatino of necrosis and apoptosis (programmed cell death) by multiparameter flow cytometry. Biochirn. Biophys. Acta 1133,275-285. Donehower, L. , Slagle, B. , McArthur, M. , Montegomery, C. , Butel, J . ,and Bradley, A. (1992). Mice deficient for p53 are develomentally normal but susceptible to spontaneous tumours. Nature (London) 356,215-221. , and Bishop, J. M. (1991). The myc protein activates transcription of the alpha-prothymosin gene.

M. (1995). Effect of caffeine on radiation-induced apoptosis in TK6 cells. Radiat. Res. 141. 170-175. 53 Structure and Function of Interleukin-lp Converting Enzyme MICHAEL J. TOCCI Department of Molecular Immunology Merck Research Laboratories Rahway, New Jersey 07065 I. Introduction 11. The IL-1 System 111. Molecular and Biochemical Characterization of ICE A. Substrate Specificity B. Purification C. ICE Enzymology D. Molecular Biology IV ICE Gene Family Members V. Biological Role of ICE A. Role of ICE in IL-lp Processing and Secretion B.

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